Technology
A New Paradigm in Dermatology and Cosmetic Science
For decades, the skin has been considered an effective barrier against large and complex biomolecules. As a result, advanced biological entities such as nucleic acids were traditionally limited to injections or invasive delivery routes.
Recent scientific evidence has fundamentally changed this perspective.
Topical mRNA/LNP Technology
Scientific Proof
Published research shows topical mRNA/LNP can cross the skin barrier, reach viable cells, and trigger functional protein expression.
From Proof to Platform
KUHS LABORATORY is translating these findings into scalable, patent-backed topical mRNA/LNP platforms for dermatology and advanced cosmetic science.
Why mRNA Outperforms Proteins
Unlike topical proteins, mRNA enables living cells to produce the protein internally, offering higher cell efficiency through transient, non-integrative expression.
Delivery & Targeting
Skin-optimized LNP architectures and optional targeting (peptides/antibodies e.g., TfR-based) support barrier interaction, targeted cell entry, and controlled intracellular release.
Supported Topical mRNA/LNP Payloads
Growth Factors
Skin renewal, wound healing, barrier repair, cosmetic rejuvenation.
Longevity & Stress Response
e.g., SIRT1, FOXO3 for resilience and metabolic regulation.
Partial Reprogramming (OSK)
Epigenetic rejuvenation via transient, non-integrative mRNA expression.
Receptor-Interacting Proteins
Skin signaling, barrier communication, immune modulation.
Phage-Derived Enzymes
Targeted antimicrobial activity, precision selectivity, safety advantages.
Immunomodulators
Local and trans-dermal signaling for inflammatory skin conditions.
Personalized Neoantigens
Topical neoantigen mRNA concepts for skin-related oncology applications.
Custom Payloads
Custom mRNA payloads designed for specific research or clinical objectives.
Access, Collaboration & Licensing
KUHS LABORATORY provides defined topical mRNA/LNP platforms, custom mRNA/LNP design, and platform access for research and development. Licensing options are available for partners interested in the technology and production protocols. All projects begin with a scientific review and feasibility assessment.
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